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Jeffrey Chalmers

  • Professor, Chemical & Biomolecular Eng
  • 483 CBEC
    151 W. Woodruff Ave.
    Columbus, OH 43210
  • 614-292-2727

About

Education

B.A., Westmont College, 1983 
B.S., U.C. Berkeley, 1983 
Ph.D., Cornell University, 1988

 

Top Honors

  • Cell Culture Engineering Award lecture, May 2016
  • Cell Culture Engineering Award, Engineering Conference International, 2014 (global, bi-annual award)
  • OSU College of Engineering Lumley Research Award: 2011,  2006, 2001, 1997, 1993
  • Fellow, American Associate for the Advancement of Science, 2005
  • AIChE 15C plenary lecture, 2005
  • OSU College of Engineering Harrison Award, 2003
  • Fellow, American Institute for Medical and Biological Engineering (AIMBE), 2001 
  • Distinguished Multidisciplinary Team Research Award, Ohio Agricultural Research and Development Center and The Ohio State University, 1996
  • NSF Young Investigator Award, 1992-97
  • Member, Tau Beta Pi, Phi Beta Kappa, Sigma Xi
 
RESEARCH AREAS - Chalmers Laboratory for Cell Analysis and Separation 

​Mankind is currently experiencing a revolution in our understanding of biological processes, from those occurring in "simple" bacteria to those occurring in human beings. Like other scientific revolutions of the past, rapid scientific advances lead to rapid development of engineering disciplines to assist in the understanding and application of this new knowledge. We are seeing this take place today in the development of the discipline of "bioengineering." Bioengineering is a broad term and includes the application of engineering principles to biological processes. 

My research is in the area of bioengineering. I have current interest/ projects in the broad areas of cell culture, ranging from the study of human stem and cancer cells to industrially relevant cells. I also have interest in the emerging area of functional genomics, especially as it is related to cell culture, cell separation, and cancer cells. 

One specific project involves the ability to identify and separate cells based on specific immunological markers. In collaboration with a colleague at the Cleveland Clinic Foundation, we have developed three new, patented immunomagnetic instruments. One of these instruments is an analytical device, while the other two are separation instruments. All three of these instruments have a large number of applications as indicated by the research support that includes the National Cancer Institute, the National Science Foundation, the Whitaker Foundation, and a private corporation. Some of these applications include: human stem cell separation for bone marrow transplants, isolation/separation of rare cancer cells circulating in human blood, and identification and separation of genetically engineered cells with specific phenotypes. Besides studying the engineering principles of this separation approach, exciting fundamental and applied biological questions are being addressed with respect to these isolated cells using the latest molecular techniques. 

 Another research area involves the development of better fundamental understanding and scale-up criteria for bioprocesses using animal cells. While large-scale animal cell culture has become quite common, a number of important questions/issues remain unresolved. For example, what is the optimum hydrodynamic environment for a suspended or anchorage- dependent cell? What is the mechanism of action, from a molecular point of view, of surface active agents in cell culture medium? Finally, my research group is exploring collaborations with systems research faculty to develop approaches to understand the great wealth of genetic information which is rapidly becoming available. This research will have specific applications with respect to the cancer cell separation projects as well as more general interest.

Honors

  • 2014

    Cell Culture Engineering 2014. .

  • 2011

    Lumley Research Award. .

  • 2006

    Lumley Research Award. .

  • 2005

    AAAS Fellow.

  • 2005

    15C plenary lecture. .

  • 2003

    Harrison Award. .

  • 2001

    Fellow. .

  • 2001

    Lumley Research Award. .

  • 1998

    Annual Research Accomplishment Award. .

  • 1997

    Lumley Research Award. .

  • 1996

    Distinguished Multidisciplinary Team Research Award. .

  • 1993

    Lumley Research Award. .

  • 1992

    National Young Investigator Award. .

  • 1989-1991

    DuPont Young Faculty Development Award. .

  • Member. .