National Gateway Ultrahigh Nuclear Magnetic Resonance Center
A cutting-edge ultrahigh field 1.2 GHz nuclear magnetic resonance (NMR) spectrometer, funded by the National Science Foundation (NSF), is the centerpiece of the new National Gateway Ultrahigh Field NMR Center at Ohio State's Campus Chemical Instrument Center (CCIC), which provides state-of-the-art research facilities for the entire campus in three areas: Nuclear Magnetic Resonance, Mass Spectrometry and Proteomics.
The CCIC's 1.2 GHz NMR spectrometer, took more than ten years to develop and is the most powerful of its kind. It is the first 1.2 GHz instrument in North America. Currently, there are only six 1.2GHz NMR spectrometers in the world.
With this 1.2GHz NMR, researchers can look into molecules at an unprecedented level--reminiscent of an MRI, but at the molecular level, with a magnetic field that is more than ten times as powerful as an average MRI scanner. It will provide a plethora of new insights into diseases, new materials, and living organisms.
The state-of-the-art CCIC NMR is a campus-wide core facility that currently houses eight high resolution Bruker NMR spectrometers (600 to 850 MHz) with a range of capabilities: powerful dynamic nuclear polarization (DNP) capabilities, high-sensitivity cryoprobes for biomolecular studies, high throughput sample changers for metabolomics, solid state probes for biomolecules and materials, micro-imaging and diffusion.
The facility and resources are available to all scientists within and outside Ohio State. The NMR is being funded through NSF's recent Mid-scale Research Infrastructure-1 program and adds to the already impressive array of instrumentation available at CCIC.
Within the William G. Lowrie Department of Chemical and Biomolecular Engineering, several research groups use this next-generation NMR instrument.
In the Winston Ho research group, students have used NMRs (both 1H and 13C) to characterize new membrane polymers and materials. The Ho Group will continue using NMR instruments for their current research projects.
Other researchers working in the fields of biomolecular NMR of proteins and nucleic acids in solution and in the solid state, materials science, and metabolomics also have uses for the instrument.
No matter what your field of study is, the CCIC NMR Facility can help take your research to a whole new level. With high-field NMR spectroscopy you can:
- Probe the active site of catalytic materials (Brunelli Research Group)
- Determine atomic resolution three dimensional structures of important biological macromolecules in solution and solid state
- Investigate molecular motions from picoseconds to seconds and beyond that are important for understanding their functions
- Unravel the underlying mechanism of biological function from molecular to atomic level
- Characterize protein-protein, protein-DNA and protein-small molecule interactions
- Discover and develop of new and improved drugs
- Evaluate newly synthesized small-molecules and isolated natural products
- Image the porosity of materials and the mobility of trapped solvent molecules
Read more about NMR capabilities here.
Please visit the CCIC NMR website for more information.