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Shang-Tian Yang

  • Professor, Food Science & Technology
  • Professor, Chemical & Biomolecular Eng
  • 482 CBEC
    151 W. Woodruff Ave.
    Columbus, OH 43210
  • 614-292-6611

About

Education

  • B.S., National Taiwan University, 1976
  • M.S.E., Purdue University, 1980
  • Ph.D., Purdue University, 1984

 

Key Honors and Distinctions

  • AIChE Division 15 Food, Pharmaceuticals & Bioengineering Plenary Lecture Award (2011)
  • Fellow, American Institute of Medical and Biological Engineering (2007)
  • Du Pont Young Faculty Award (1989-91)
  • Outstanding Contribution Award, Chinese Academic and Professional Assocn. in Mid-America (1992)
  • Lumley Research Award, College of Engineering, Ohio State University (1995; 2001; 2007; 2013)
  • Research Accomplishment Award, College of Engineering, Ohio State University (1997)
  • Four patents.

 

RESEARCH AREAS - Yang Group for Bioprocessing and Tissue Engineering
  • Biotechnology, Bioengineering, and Bioprocessing. Our current research program covers two important areas in bioprocessing and bioengineering. The first one is animal cell culture and tissue engineering; the second one is bioprocessing for value-added products. 
  • Current research projects: novel bioprocesses for value-added products from biomass, metabolic engineering of anaerobic bacteria for enhanced production of chemicals and biofuels, novel bioreactors for fermentation and cell and tissue cultures, in vitro expansion and differentiation of embryonic stem cells, microfluidic biochips for biodiagnostics and high-throughput drug screening.

  • Graduate student research opportunities are currently available.

  • PUBLICATIONS AND PATENTS

Animal Cell Culture and Tissue Engineering

We have developed a perfusion bioreactor with a fibrous matrix to support high-density, viable cell population for long-term production of recombinant proteins and tissue engineering of human cells. We have found that the 3-D fibrous matrix has profound effects on cell spatial organization, morphology, and cell-cell contacts and interactions, which in turn affect cell proliferation, differentiation, and functions. Cells grown in the fibrous matrix maintained better long-term stability, as compared to those grown in T-flasks. Ovary luteal cells cultured in the 3-D matrix maintained their cellular function to secrete progesterone, while cells cultured in the 2-D static flask lost most of their response in the same culturing period. 

We are working on tissue engineering of human cells for various biomedical applications. For example, an in vitro human placenta model system based on tissue engineering of human trophoblast cells is being developed for drug screening and toxicology studies. 

Bioprocessing for Value-Added Products
It is important for agricultural and food industries to increase their product values through the uses of modern biotechnology and bioprocesses. Our work has been concentrated on the development of several novel bioprocesses for economical production of high-value products from food processing wastes and agricultural commodities. Our recent and ongoing research projects include fermentation of whey permeate and plant biomass to produce various organic acids and microbial polysaccharides, steroid biotransformation, and immobilized enzyme for galactooligosaccharides (GOS) production. These bioprocesses are important to the agricultural industry and address important environmental issues. One example is the process we developed to convert whey permeate, a dairy waste, to environmentally friendly, non-corrosive road deicers. 

We take an integrated approach to solve an important bioprocess engineering problem: a patented fibrous-bed bioreactor is developed to increase productivity and cell tolerance to a high-concentration of inhibitory metabolites; membrane separation and solvent extraction are used to separate and concentrate fermentation products; and genetic and metabolic engineering of production cells are used to further improve product yields and process efficiency. We are also interested in applying our technology in the environmental area, such as biofiltration of VOC and biodegradation of hazardous chemicals in industrial waste streams and contaminated groundwater.

Honors

  • 20130101

    Lumley Research Award.

  • 20110101

    AIChE Division 15 Food, Pharmaceuticals & Bioengineering Plenary Lecture Award.

  • 20070101-20071201

    Fellow.

  • 20070101-20071201

    Lumley Research Award.

  • 20050901-20060201

    Visiting professorship.

  • 20010101-20011201

    Lumley Research Award.

  • 19980301-19980601

    Visiting professorship.

  • 19971001-19980201

    Visiting professorship.

  • 19970101-19971201

    Research Accomplishment Award.

  • 19960601-19960901

    Visiting lectureship.

  • 19950101-19951201

    Lumley Research Award.

  • 19920101-19921201

    Outstanding Contribution Award.

  • 19890101-19910101

    Du Pont Young Faculty Award.

  • 19910101

    DuPont Young Faculty Award.

Presentations

  • ""Metabolic engineering of Clostridia for production of biofuels." 2009, Presented at keynote for the session on "Bioenergy" BioEcon2009, Tianjin, China,
  • ""Bioprocess and metabolic engineering for production of biobased chemicals." 2011, Presented at keynote for the session on "Industrial Biotechnology" BioEco2011, Tianjin, China,
  • "Bio-butanol production technologies with agricultural biomass." 2009, Presented at Keynote at the APEC Workshop on Developing Bioenergy and Conserving the Natural Ecosystem in APEC Member Economies, Seoul, South Korea,

Papers in Proceedings

2014

  • Dong,Jie; Du,Yinming; Zhou,Yipin; Yang,Shang-Tian "Butanol Production from Soybean Hull and Soy Molasses by Acetone-Butanol-Ethanol Fermentation." in Symposium on Biobased Chemicals and Materials: Growing the Supply Chain / 17th Annual ACS Green Chemistry and Engineering Conference. (1 2014).

2009

  • S.T. Yang "Bio-butanol production technologies with agricultural biomass." (9 2009).
  • Fan,Li-Hai; Yu,Mingrui; Yang,Shang-Tian; Chen,Huan-Lin "BIOT 279-Cell surface display of carbonic anhydrase on Escherichia coli using ice nucleation protein." (8 2009).

2003

  • S.T. Yang "Animal cell culture in three-dimensional fibrous matrix." (12 2003).

2001

  • W. Qin and S.T. Yang "Strategies for extraction methods in the extractive fermentation process of 27 carboxylic acid.." (1 2001).
  • Abdullatif Tay, Shang-Tian Yang, and Belgin Candas "A Novel Fermentation Process for Production of Lactic Acid from Starch Using Immobilized Cells of Rhizopus oryzae." in II. Southeastern Anatolia Project (SAP) Agriculture Congress. (10 2001).

2000

  • B. Doma, Jr., J. Salvacion, and S.T. Yang "Improved Xanthan Gum Fermentation Using a Novel Rotating Fibrous-Bed Bioreactor System." in 61st PIChE National Convention. (2 2000).
  • E.C. San Nicolas, J. Salvacion, and S.T. Yang "A Novel Extractive Fermentation System for Enhanced Acetate Production." in 61st PIChE National Convention. (2 2000).
  • S.A. Valencia, J. Salvacion, and S.T. Yang "Corn Fiber as Adsorption for the Rmoval of Basic and Reactive Dyes from Simulated Textile Wasteeater." in 61st PIChE National Convention. (2 2000).

1998

  • A.L. Kneidel, H. Shim, and S.T. Yang "Trichloroethylene bioremediation by Mythylosinus trichosporium OB3b immobilized in a fibrous-bed bioreactor. In Bioremediation and Phytoremediation: Chlorinated and Recalcitrant Compounds." in First International Conference on Remediation of Chlorinated and Recalcitrant Compounds. (1 1998).
  • Y. Huang, Z. Jin, Y.L. Huang, and S.T. Yang "Metabolic Engineering and Extractive Fermentation for Enhanced Propionate Production from Glucose." (1 1998).

1997

  • S.T. Yang, Zuwei Jin, and B.H. Chollar "Production of Low-Cost Acetate Deicers from Biomass and Industrial Wastes." in Snow Removal and Ice Control Technology, Transportation Research Board. (1 1997).
  • E.M. Silva and S.T. Yang "A Novel Spouted Bed Bioreactor for Solid State Fermentation." in 5th Conference of Food Engineering. (11 1997).
  • Q. Wei and S.T. Yang "Separation of Acetic and Lactic Acid in Fermentation by Solvent Extraction Using Hollow Fiber Membrane Extractor." in AIChE Annual meeting. (11 1997).
  • S.T. Yang "Pollution Prevention and Waste Minimization: Novel Bioprocessing Technologies for Biochemicals Production and Waste Reduction." in Asian Pacific Conference on Industrial Waste Minimization and Sustainable Development. (12 1997).

1996

  • S.T. Yang and B.H. Chollar "Production of Low-Cost Acetate Deicers from Biomass and Industrial Wastes." in 4th International Symposium on Snow Removal and Ice Control Technology, Reno, Nevada. (8 1996).

1995

  • S.T. Yang, Y.-M. Lo, Y. He, and Z. Jin "Novel Fermentation and Separation Processes for Pollution 26 Prevention and Waste Reduction in the Fermentation Industry." in Mid-American Chinese Professional Annual Convention. (6 1995).

1993

  • S.T. Yang, H. Zhu, Y. Li, and I.C. Tang "Production of Low-Cost Calcium Magnesium Acetate (CMA) as an Environmentally Friendly Deicer from Cheese Whey." in First Biomass Conference of The Americas. (9 1993).
  • S.T. Yang, H. Zhu, and E.M. Silva "Production of Value-Added Products from Agricultural and Food Processing Byproducts." in Ninth National Convention of Chemical Engineers and International Symposium on Importance of Biotechnology in Coming Decades. (6 1993).
  • S.T. Yang, H. Zhu, Y. Li, and E.M. Silva "A Novel Multi-Phase Bioreactor for Fermentations to Produce Organic acids from Dairy Wastes." in First Biomass Conference of The Americas. (9 1993).

1992

  • S.T. Yang, H. Zhu, and Y. Li "Calcium Magnesium Acetate (CMA) Production from Whey Permeate." in Dairy Products Technical Conference,. (1 1992).

1991

  • S.T. Yang "A Novel Method to Produce Road Deicer from Cheese Whey." in Waste Stream Minimization and Utilization Innovative Concepts - An Experimental Technology Exchange, Washington D.C.. (4 1991).

1989

  • S.T. Yang "Waste Minimization in Food, Pharmaceutical and Forestry Industries." in AIChE/EPA/NSF Workshop on Waste Minimization Research Needs. (1 1989).
  • S.T. Yang "Pollution Prevention and Waste Minimization in the Dairy Industry through Novel Uses of Whey Permeate." in AIChE Pollution Prevention Conference, Washington, D.C.. (1 1989).

1984

  • S.T. Yang, I.C. Tang, and M.R. Okos "Methane and Methanol from Food and Agricultural Wastes." in symposium paper, 4th Annual Solar & Biomass Energy Workshop. (4 1984).

1983

  • S.T. Yang, I.C. Tang, and M.R. Okos "Methanol Production from Food and Agricultural Wastes." in symposium paper, 3rd Annual Solar & Biomass Energy Workshop. (4 1983).

1982

  • S.T. Yang, M.R. Okos, and J.C. Nye "Fermentation Kinetics of Anaerobic Methanogenesis from Cheese Whey." in ASAE Winter Meeting, Palmer House, Chicago, IL. (1 1982).