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Shang-Tian Yang

  • Professor, Food Science & Technology
  • Professor, Chemical & Biomolecular Eng
  • 482 CBEC
    151 W. Woodruff Ave.
    Columbus, OH 43210
  • 614-292-6611

About

Education

  • B.S., National Taiwan University, 1976
  • M.S.E., Purdue University, 1980
  • Ph.D., Purdue University, 1984

 

Key Honors and Distinctions

  • AIChE Division 15 Food, Pharmaceuticals & Bioengineering Plenary Lecture Award (2011)
  • Fellow, American Institute of Medical and Biological Engineering (2007)
  • Du Pont Young Faculty Award (1989-91)
  • Outstanding Contribution Award, Chinese Academic and Professional Assocn. in Mid-America (1992)
  • Lumley Research Award, College of Engineering, Ohio State University (1995; 2001; 2007; 2013)
  • Research Accomplishment Award, College of Engineering, Ohio State University (1997)
  • Four patents.

 

RESEARCH AREAS - Yang Group for Bioprocessing and Tissue Engineering
  • Biotechnology, Bioengineering, and Bioprocessing. Our current research program covers two important areas in bioprocessing and bioengineering. The first one is animal cell culture and tissue engineering; the second one is bioprocessing for value-added products. 
  • Current research projects: novel bioprocesses for value-added products from biomass, metabolic engineering of anaerobic bacteria for enhanced production of chemicals and biofuels, novel bioreactors for fermentation and cell and tissue cultures, in vitro expansion and differentiation of embryonic stem cells, microfluidic biochips for biodiagnostics and high-throughput drug screening.

  • Graduate student research opportunities are currently available.

  • PUBLICATIONS AND PATENTS

Animal Cell Culture and Tissue Engineering

We have developed a perfusion bioreactor with a fibrous matrix to support high-density, viable cell population for long-term production of recombinant proteins and tissue engineering of human cells. We have found that the 3-D fibrous matrix has profound effects on cell spatial organization, morphology, and cell-cell contacts and interactions, which in turn affect cell proliferation, differentiation, and functions. Cells grown in the fibrous matrix maintained better long-term stability, as compared to those grown in T-flasks. Ovary luteal cells cultured in the 3-D matrix maintained their cellular function to secrete progesterone, while cells cultured in the 2-D static flask lost most of their response in the same culturing period. 

We are working on tissue engineering of human cells for various biomedical applications. For example, an in vitro human placenta model system based on tissue engineering of human trophoblast cells is being developed for drug screening and toxicology studies. 

Bioprocessing for Value-Added Products
It is important for agricultural and food industries to increase their product values through the uses of modern biotechnology and bioprocesses. Our work has been concentrated on the development of several novel bioprocesses for economical production of high-value products from food processing wastes and agricultural commodities. Our recent and ongoing research projects include fermentation of whey permeate and plant biomass to produce various organic acids and microbial polysaccharides, steroid biotransformation, and immobilized enzyme for galactooligosaccharides (GOS) production. These bioprocesses are important to the agricultural industry and address important environmental issues. One example is the process we developed to convert whey permeate, a dairy waste, to environmentally friendly, non-corrosive road deicers. 

We take an integrated approach to solve an important bioprocess engineering problem: a patented fibrous-bed bioreactor is developed to increase productivity and cell tolerance to a high-concentration of inhibitory metabolites; membrane separation and solvent extraction are used to separate and concentrate fermentation products; and genetic and metabolic engineering of production cells are used to further improve product yields and process efficiency. We are also interested in applying our technology in the environmental area, such as biofiltration of VOC and biodegradation of hazardous chemicals in industrial waste streams and contaminated groundwater.

Honors

  • 20130101

    Lumley Research Award.

  • 20110101

    AIChE Division 15 Food, Pharmaceuticals & Bioengineering Plenary Lecture Award.

  • 20070101-20071201

    Fellow.

  • 20070101-20071201

    Lumley Research Award.

  • 20050901-20060201

    Visiting professorship.

  • 20010101-20011201

    Lumley Research Award.

  • 19980301-19980601

    Visiting professorship.

  • 19971001-19980201

    Visiting professorship.

  • 19970101-19971201

    Research Accomplishment Award.

  • 19960601-19960901

    Visiting lectureship.

  • 19950101-19951201

    Lumley Research Award.

  • 19920101-19921201

    Outstanding Contribution Award.

  • 19890101-19910101

    Du Pont Young Faculty Award.

  • 19910101

    DuPont Young Faculty Award.

Presentations

  • "Metabolic and process engineering for enhanced production of biofuels and biochemicals." 2007, Presented at The 11th Annual Symposium on Industrial and Fermentation Microbiology, University of Wisconsin-La Crosse, La Crosse, WI,
  • "Value-added products from biorenewable resources." 2007, Presented at Institute of Bioengineering, Zhejiang University, Hangzhou, China,
  • "Metabolic and Process Engineering for Economical Production of Biofuels and Biochemicals." 2007, Presented at The International Conference on Biorefinery, Beijing, China,
  • "Microbioreactor Arrays for High-Throughput Screening (HTS) for Drug Discovery and Bioprocess Development." 2007, Presented at National Tsing-Hua University, Hsin-Chu, Taiwan,
  • "A Two-Stage Perfusion Bioreactor System for Mass Production of Embryonic Stem Cells." 2008, Presented at Institut für Bioprozess- und Biosystemtechnik, Technische Universität Hamburg-Harburg, Hamburg, Germany,
  • "“Metabolic and evolutionary engineering of Clostridia for biobutanol production." 2010, Presented at Institute of Bioengineering, Zhejiang University, Hangzhou, China,
  • "Microbioreactor Arrays for High-Throughput Screening (HTS) for Drug Discovery and Bioprocess Development." 2008, Presented at BioTechnology Institute, University of Minnesota, St. Paul, MN,
  • "Fibrous-Bed Bioreactor: from Fermentation to Cell Cultures and Biochips." 2008, Presented at Chongqing University, China,
  • "Fibrous-bed bioreactor: from fermentation to cell cultures and biochips." 2008, Presented at National Cheng Kung University, China,
  • "Fibrous-bed bioreactor: from fermentation to cell culture, tissue engineering and high-throughput screening for drug discovery." 2009, Presented at Seoul National University, Seoul, South Korea,
  • "Integrated biorefinery – Production of biofuels and biochemicals from biorenewable resources." 2009, Presented at Mapua Institute of Technology, Manila, Philippines,
  • "High throughput screening for biomolecule discovery." 2010, Presented at Plenary lecture, 3rd International Conference on Biotechnology for the Wellness Industry (ICBWI), Putra World Trade Centre, Kuala Lumpur, Malaysia,
  • "Metabolic engineering of Clostridia for production of biofuels and bio-based chemicals." 2011, Presented at Arizona State University, Tempe, AZ,
  • "Bioprocessing for value-added products: from prebiotics to biofuels." 2007, Presented at South China University of Technology, Guangzhou, China,
  • "Metabolic engineering of Clostridia for butanol production." 2010, Presented at Nagarjuna Fertilizer and Chemical Ltd. (NFCL), Hyderabad, India,
  • "Metabolic and process engineering for enhanced production of biofuels and biochemicals." 2008, Presented at Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China,
  • "Bioprocess engineering for production of biobased industrial products from agricultural residues and food processing wastes." 2009, Presented at keynote for the session on "Industrial and Environmental Biotechnology" 9 BioEco2009, Tianjin, China,
  • "Fibrous-bed bioreactor: from fermentation to cell cultures and high-throughput screening for drug discovery." 2009, Presented at Sarawak Biodiversity Centre, Kuching, Sarawak, Malaysia,
  • "Bioprocess Engineering and Biofactories workshop." 2011, Presented at Institute of Bioproduct Development, University Technology Malaysia (UTM), Johor Bahru, Malaysia,
  • "Metabolic and evolutionary engineering of Clostridia for biobutanol production." 2011, Presented at Centre for Sustainable Chemical Technologies Summer Showcase, Bath University / OSU / RWTH Aachen symposium, Bath, United Kingdom,
  • "Production of butyric acid and butanol from corn in a two-step fermentation process." 2007, Presented at Cathay Biotechnology, Shanghai, China,
  • "Production of biofuels and biochemicals from plant biomass." 2007, Presented at BioEcon 2007, Tianjin, China,
  • "Microbioreactor arrays for high-throughput cytotoxicity assay and drug screening." 2007, Presented at Cell-Based Assays for HTS Conference, Cambridge Health Institute's World Pharmaceutical Congress, Philadelphia, PA,
  • "Metabolic engineering for enhanced production of biofuels and biochemicals." 2007, Presented at School of Pharmacey and Life Science, Nanjing University of Technology, Nanjing, China,
  • "Bioprocess and metabolic engineering for production of biofuels and bio-based chemicals." 2009, Presented at College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China,
  • ""Metabolic engineering of Clostridia for production of biofuels." 2009, Presented at keynote for the session on "Bioenergy" BioEcon2009, Tianjin, China,
  • "Cell-based high throughput screening for biomolecule discovery and bioprocess development." 2009, Presented at Plenary lecture, 2nd International Conference on Biotechnology for the Wellness Industry, Putra World Trade Centre, Kuala Lumpur, Malaysia,
  • "Bioprocess engineering: from prebiotics to biofuels and biochips." 2009, Presented at Faculty of Chemical Engineering and Natural Resources, University Technology Malaysia (UTM), Johor Bahru, Malaysia,
  • ""Bioprocess and metabolic engineering for production of biobased chemicals." 2011, Presented at keynote for the session on "Industrial Biotechnology" BioEco2011, Tianjin, China,
  • "“Bioprocess engineering: from prebiotics to biofuels and biochips." 2009, Presented at Plenary Lecture, 14th Biochemical Engineering Conference, National Chung Hsing University, Taichung, Taiwan,
  • "Cell-Based High-Throughput Screening (HTS) for Cytotoxicity and Drug Discovery." 2008, Presented at Faculty of Pharmacy, Alexandria University, Alexandria, Egypt,
  • "A spouted bed bioreactor for solid state fermentations to produce enzymes and chemicals." 2008, Presented at Bioprocess Development Dept., Mubarak City for Scientific Research and Technology Applications, Alexandria, Egypt,
  • "Metabolic and process engineering for enhanced production of biofuels and biochemicals." 2008, Presented at Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul, MN,
  • "3-D cell cultures in fibrous bed bioreactor: from protein production to tissue engineering and highthroughput screening." 2008, Presented at BioInnovation RedCarpetDay 2008, Knightsbridge, London, UK,
  • "3-D cell cultures in fibrous bed bioreactor: from protein production to regenerated medicine and highthroughput screening." 2008, Presented at Department of Biochemical Engineering, University College London, London, UK,
  • "Microbioreactor arrays for high-throughput screening (HTS) in drug discovery and bioprocess development." 2009, Presented at 3rd Tokyo University of Science International Collaboration Workshop, Tokyo, Japan,
  • "Three-dimensional cultures for expansion and differentiation of embryonic stem cells." 2009, Presented at National Tsing-Hua University, Hsin-Chu, Taiwan,
  • "Metabolic engineering of Clostridia for production of biofuels and bio-based chemicals." 2009, Presented at Institute of Bioengineering, Zhejiang University, Hangzhou, China,
  • "Biorefinery: Production of biofuels and biobased chemicals and materials"." 2009, Presented at National Taiwan University, Taipei, Taiwan,
  • "Cell-based high throughput screening for drug discovery and bioprocess development." 2009, Presented at University of the Philippines Diliman, Philippines,
  • "Bio-butanol production technologies with agricultural biomass." 2009, Presented at Keynote at the APEC Workshop on Developing Bioenergy and Conserving the Natural Ecosystem in APEC Member Economies, Seoul, South Korea,
  • "Enhanced production of biofuels and biochemicals." 2007, Presented at Fifth Tripartite Workshop in Biotechnology and BioEnergy, Rutgers, The State University of New Jersey, The University of São Paulo, Brazil, and The Ohio State University,
  • "Bioprocessing for value-added products: from prebiotics to biofuels." 2007, Presented at Enhancing Linkages between Universities and Small Businesses, National NSF EPSCoR/USDA SBIR Conference, South Portland, Maine,
  • "Future of biofuel technologies: Metabolic and process engineering for economical production of biofuels." 2008, Presented at SAARC Regional Workshop on Biofuels, Hotel Heritance Kandalama, Dambulla, Sri Lanka,
  • "Bioprocess engineering: from prebiotics to biofuels and biochips." 2008, Presented at Postgraduate Institute of Agriculture, University of Peradeniya, Peradeniya, Sri Lanka,
  • "Metabolic and process engineering for economic production of biofuels and biochemicals." 2008, Presented at Center for Environmental Technology Research, Korea Institute of Science and Technology (KIST), Seoul, South Korea,
  • "Microbioreactor arrays for high-throughput screening (HTS) in drug discovery and bioprocess development." 2008, Presented at Institute of Bioengineering, Zhejiang University, Hangzhou, China,
  • "Three-dimensional cultures for expansion and differentiation of embryonic stem cells." 2009, Presented at University of the Philippines Diliman, Philippines,
  • "Novel two-stage process for the production of butanol from biomass." 2009, Presented at Mapua Institute of Technology, Manila, Philippines,
  • "Integrated biorefinery – Production of biofuels and biochemicals from biorenewable resources." 2009, Presented at University of San Carlos in Cebu, Philippines,
  • "Biofuels from an international perspective: Integrated biorefinery – Production of biofuels and biochemicals from biorenewable resources." 2008, Presented at SAARC Regional Workshop on Biofuels, Hotel Heritance Kandalama, Dambulla, Sri Lanka,
  • "A Two-Stage Perfusion Bioreactor System for Mass Production of Embryonic Stem Cells." 2007, Presented at CELLutions SUMMIT, Cambridge Healthtech Institute’s Third Annual Stem Cell Sources: Targeting Cell-Based Regenerative Therapies, World Trade Center, Boston, MA,
  • "Bioproduction of propionic acid and propanol from renewable resources." 2010, Presented at Dow Chemical, Freeport, TX,
  • "Bioprocess and metabolic engineering for carboxylic acids production from biomass." 2011, Presented at Eastman Chemical Company, Kingsport, TN,
  • "Metabolic Engineering for Enhanced Propionic Acid Fermentation by Propionibacterium acidipropionici." 2007, Presented at Recent Advances in Fermentation Technology VII ( RAFTVII), St. Petersburg, FL,
  • "Metabolic engineering and process development for production of carboxylic acids from waste sugars and glycerol." 2007, Presented at Recent Advances in Fermentation Technology VII ( RAFTVII): Fermentation Process and Product Improvement - Advancements in physiology and metabolic studies, St. Petersburg, FL,
  • "Metabolic and Process Engineering for Enhanced Production of Biofuels and Biochemicals." 2007, Presented at Asia- Pacific Biochemical Engineering Conference 2007 (APBioCHEC 2007), Taipei, Taiwan,
  • "A Two-Stage Perfusion Bioreactor System for Mass Production of Embryonic Stem Cells." 2007, Presented at National Taiwan University, Taipei, Taiwan,
  • "Functional Genomics and Metabolic Engineering for Enhanced Production of Biofuels and Biochemicals." 2008, Presented at Genetic Engineering and Biotechnology Centre, Monofia University, Egypt,
  • "3-D cell cultures in fibrous bed bioreactor: from protein production to tissue engineering and highthroughput screening." 2008, Presented at Faculty of Chemical Engineering and Natural Resources, University Technology Malaysia (UTM), Johor, Malaysia,
  • "Metabolic and Process Engineering for Enhanced Production of Biofuels and Biochemicals." 2008, Presented at Institut für Bioprozess- und Biosystemtechnik, Technische Universität Hamburg-Harburg, Hamburg, Germany,
  • "Engineering microbes for chemicals production from process engineering perspectives." 2008, Presented at Third National Microbial Genetics and 7th Basic Microbiology Young Scientists Symposium, Jinan, Shangdong, China,
  • "Biorefinery: Production of biofuels and biobased chemicals and materials." 2008, Presented at Bioenergy Symposium, Chinese Academy of Sciences Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT), Qingdao, China,
  • "Bioprocess engineering workshop." 2010, Presented at Chemical Engineering Pilot Plant (CEPP), University Technology Malaysia (UTM), Johor Bahru, Malaysia,
  • "“Metabolic and process engineering of Clostridia for production of biofuels and bio-based chemicals." 2009, Presented at University of the Philippines Los Banos (UPLB), Philippines,
  • "Metabolic and Process Engineering for Biobutanol Production from Biomass." 2007, Presented at New and Renewable Energy Forum, the 10th Guangzhou Convention of Overseas Chinese Scholars in Science and Technology, organized by Guangzhou Institute of Energy Conversion and Qingdao Institute of Biomass Energy and Bioprocess Technology, the Chinese Academy of Sciences, Guangzhou, China,
  • "Metabolic and process engineering for enhanced production of biofuels and biochemicals." 2008, Presented at 13th International Biotechnology Symposium and Exhibition, Dalian, China,
  • "Embryonic stem cells for regenerative medicine and drug discovery." 2007, Presented at National Institute of Dental and Craniofacial Research, National Institute of Health,
  • "Metabolic and process engineering for enhanced production of biofuels and biochemicals." 2008, Presented at College of Bioengineering, Jiang-Nan University, Wuxi, China,
  • "Cell-based high-throughput screening (HTS) in microbioreactor arrays for drug discovery and bioprocess development." 2008, Presented at College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, China,,
  • "A two-stage perfusion bioreactor system for mass production of embryonic stem cells." 2008, Presented at College of Biotechnology and Life Science, South China University of Technology, Guangzhou, China,
  • "Metabolic engineering of Clostridia for production of biofuels and bio-based chemicals." 2009, Presented at Guangxi Academy of Science, Nanning, Guangxi, China,
  • "Cell-based high-throughput screening (HTS) in microbioreactor arrays for drug discovery and bioprocess development." 2009, Presented at International Symposium on Bioprocess and Biosystems Engineering 2009 (ISBBE 2009), East China University of Science and Technology (ECUST), Shanghai, China,
  • "Cell-based fluorescent assay for high throughput screening of biologically active compounds." 2009, Presented at Global Chinese Health (Functional) Food Symposium 2009, The University of Hong Kong, Hong Kong,
  • "Biorefinery: Production of biofuels and biobased chemicals and materials." 2009, Presented at Guangxi University, Nanning, Guangxi, China,
  • "Bioprocess engineering: from prebiotics to biofuels and biochips." 2009, Presented at Jiang-Nan University, Wuxi, China,

Papers in Proceedings

2014

  • Dong,Jie; Du,Yinming; Zhou,Yipin; Yang,Shang-Tian "Butanol Production from Soybean Hull and Soy Molasses by Acetone-Butanol-Ethanol Fermentation." in Symposium on Biobased Chemicals and Materials: Growing the Supply Chain / 17th Annual ACS Green Chemistry and Engineering Conference. (1 2014).

2009

  • S.T. Yang "Bio-butanol production technologies with agricultural biomass." (9 2009).
  • Fan,Li-Hai; Yu,Mingrui; Yang,Shang-Tian; Chen,Huan-Lin "BIOT 279-Cell surface display of carbonic anhydrase on Escherichia coli using ice nucleation protein." (8 2009).

2003

  • S.T. Yang "Animal cell culture in three-dimensional fibrous matrix." (12 2003).

2001

  • W. Qin and S.T. Yang "Strategies for extraction methods in the extractive fermentation process of 27 carboxylic acid.." (1 2001).
  • Abdullatif Tay, Shang-Tian Yang, and Belgin Candas "A Novel Fermentation Process for Production of Lactic Acid from Starch Using Immobilized Cells of Rhizopus oryzae." in II. Southeastern Anatolia Project (SAP) Agriculture Congress. (10 2001).

2000

  • B. Doma, Jr., J. Salvacion, and S.T. Yang "Improved Xanthan Gum Fermentation Using a Novel Rotating Fibrous-Bed Bioreactor System." in 61st PIChE National Convention. (2 2000).
  • E.C. San Nicolas, J. Salvacion, and S.T. Yang "A Novel Extractive Fermentation System for Enhanced Acetate Production." in 61st PIChE National Convention. (2 2000).
  • S.A. Valencia, J. Salvacion, and S.T. Yang "Corn Fiber as Adsorption for the Rmoval of Basic and Reactive Dyes from Simulated Textile Wasteeater." in 61st PIChE National Convention. (2 2000).

1998

  • A.L. Kneidel, H. Shim, and S.T. Yang "Trichloroethylene bioremediation by Mythylosinus trichosporium OB3b immobilized in a fibrous-bed bioreactor. In Bioremediation and Phytoremediation: Chlorinated and Recalcitrant Compounds." in First International Conference on Remediation of Chlorinated and Recalcitrant Compounds. (1 1998).
  • Y. Huang, Z. Jin, Y.L. Huang, and S.T. Yang "Metabolic Engineering and Extractive Fermentation for Enhanced Propionate Production from Glucose." (1 1998).

1997

  • S.T. Yang, Zuwei Jin, and B.H. Chollar "Production of Low-Cost Acetate Deicers from Biomass and Industrial Wastes." in Snow Removal and Ice Control Technology, Transportation Research Board. (1 1997).
  • E.M. Silva and S.T. Yang "A Novel Spouted Bed Bioreactor for Solid State Fermentation." in 5th Conference of Food Engineering. (11 1997).
  • Q. Wei and S.T. Yang "Separation of Acetic and Lactic Acid in Fermentation by Solvent Extraction Using Hollow Fiber Membrane Extractor." in AIChE Annual meeting. (11 1997).
  • S.T. Yang "Pollution Prevention and Waste Minimization: Novel Bioprocessing Technologies for Biochemicals Production and Waste Reduction." in Asian Pacific Conference on Industrial Waste Minimization and Sustainable Development. (12 1997).

1996

  • S.T. Yang and B.H. Chollar "Production of Low-Cost Acetate Deicers from Biomass and Industrial Wastes." in 4th International Symposium on Snow Removal and Ice Control Technology, Reno, Nevada. (8 1996).

1995

  • S.T. Yang, Y.-M. Lo, Y. He, and Z. Jin "Novel Fermentation and Separation Processes for Pollution 26 Prevention and Waste Reduction in the Fermentation Industry." in Mid-American Chinese Professional Annual Convention. (6 1995).

1993

  • S.T. Yang, H. Zhu, Y. Li, and I.C. Tang "Production of Low-Cost Calcium Magnesium Acetate (CMA) as an Environmentally Friendly Deicer from Cheese Whey." in First Biomass Conference of The Americas. (9 1993).
  • S.T. Yang, H. Zhu, and E.M. Silva "Production of Value-Added Products from Agricultural and Food Processing Byproducts." in Ninth National Convention of Chemical Engineers and International Symposium on Importance of Biotechnology in Coming Decades. (6 1993).
  • S.T. Yang, H. Zhu, Y. Li, and E.M. Silva "A Novel Multi-Phase Bioreactor for Fermentations to Produce Organic acids from Dairy Wastes." in First Biomass Conference of The Americas. (9 1993).

1992

  • S.T. Yang, H. Zhu, and Y. Li "Calcium Magnesium Acetate (CMA) Production from Whey Permeate." in Dairy Products Technical Conference,. (1 1992).

1991

  • S.T. Yang "A Novel Method to Produce Road Deicer from Cheese Whey." in Waste Stream Minimization and Utilization Innovative Concepts - An Experimental Technology Exchange, Washington D.C.. (4 1991).

1989

  • S.T. Yang "Waste Minimization in Food, Pharmaceutical and Forestry Industries." in AIChE/EPA/NSF Workshop on Waste Minimization Research Needs. (1 1989).
  • S.T. Yang "Pollution Prevention and Waste Minimization in the Dairy Industry through Novel Uses of Whey Permeate." in AIChE Pollution Prevention Conference, Washington, D.C.. (1 1989).

1984

  • S.T. Yang, I.C. Tang, and M.R. Okos "Methane and Methanol from Food and Agricultural Wastes." in symposium paper, 4th Annual Solar & Biomass Energy Workshop. (4 1984).

1983

  • S.T. Yang, I.C. Tang, and M.R. Okos "Methanol Production from Food and Agricultural Wastes." in symposium paper, 3rd Annual Solar & Biomass Energy Workshop. (4 1983).

1982

  • S.T. Yang, M.R. Okos, and J.C. Nye "Fermentation Kinetics of Anaerobic Methanogenesis from Cheese Whey." in ASAE Winter Meeting, Palmer House, Chicago, IL. (1 1982).