- Professor, Biomedical Engineering
- Professor, Chemical & Biomolecular Eng
151 W. Woodruff Ave.
Columbus, OH 43210
- B.S., Northwestern University, 1997
- M.S., University of Texas at Austin, 2001
- Ph.D., University of Texas at Austin, 2004
Key Honors and Distinctions
- Inventor of the Year, TechColumbus Innovation Awards, 2013
- OSU Early Innovator Award, 2012
- OSU Distingsuihed Undergraduate Research Mentor, 2011
- OSU Lumley Research Award, 2010
- Elected Senior Member of IEEE, 2009
- ACS Progress/Dreyfus Lectureship Award, 2008
- Established leader in nanobiotechnology through the development of magnetic quantum dots for cell and molecular separations
- Nanobiotechnology, Cell and Tissue Engineering, Neural Prosthetics
"Biology is not simply writing information; it is doing something about it. A biological system can be exceedingly small. Many of the cells are very tiny, but they are very active; they manufacture various substances; they walk around; they wiggle; and they do all kinds of marvelous things---all on a very small scale. Also, they store information. Consider the possibility that we too can make a thing very small which does what we want---that we can manufacture an object that maneuvers at that level!" --Richard P. Feynman, "There is Plenty of Room at the Bottom"
Professor Winter's primary research interest is the exploration of the relationship between nanoparticles and biological elements.
This work is divided into three areas:
- Development of nanoscale neural prosthetic devices
- Patterned chemical and physical cues for improved neural adhesion and synapse formation
- Creation of oriented, nanopatterned surfaces using biological elements
Nanoscale Neural Prosthetics
The nerve cell is a fascinating model system for subcellular manipulation because it responds to chemical, mechanical, and electrical cues. Neurons have been integrated with electronic components to create hybrid electronic devices that have been used for computation, neuroscience research, and as prosthetics. Adding nanoscale manipulation to those devices will provide new insight into the biomolecular basis of disease, allow for biosensors that might detect a single molecule, harness neural networks for computation, and lead to prosthetic devices that integrate with their hosts at the cellular-level. The first area focuses on the development of nanocomponents to directly manipulate the contents of nerve cells. My initial work in this area examines the selective binding of nanoparticles to subcellular structures (i.e., ion channels, neurotransmitters, and chemical-containing vesicles). It is straightforward to attach nanoparticles to the surface of cells, but targeting specific elements in the cell's interior is more challenging. The majority of nanoparticles introduced into the cytoplasm (the fluid inside of a cell) are eventually sequestered into endosomes or lysosomes, preventing their interaction with intracellular proteins. I am exploring alternative delivery and targeting methods using techniques developed for gene therapy.
Patterning for Neural Adhesion and Synapse Formation
There is a substantial body of evidence that nanometer spacing of chemical sequences of physical patterns can effect cellular gene expression, adhesion, and migration. I am investigating the effects of nano-patterned physical and chemical cues on neuron-neuron and neuron-electrode interactions. I am particularly interested in patterns which enhance physical and electrical interfaces among nerve cells and underlying electronic devices. This technology has the potential to greatly increase the sensitivity of nerual recording devices, biosensors, and prosthetics.
The third area examines one of the most critical problems facing nanotechnology: how do we organize and arrange objects at the nanoscale? Nature has created several elegant schemes to organize elements in this size regime. For example, protein folding, DNA replication, and transport along microtubules all occur with remarkable fidelity. I am exploiting some of these methods to create "bio-inspired" surfaces. These surfaces use biomolecules to assemble and manipulate nanoparticles into coherent structures. Ultimately these structures may serve as tissue engineering substrates, biomaterial coatings, or as elements of electronic devices.
20 People to Know in Technology. Columbus Business First.
Top 25 STEM Professors in Ohio. Online Schools Ohio.
TechColumbus Inventor of the Year. TechColumbus.
Semi-Finalist Innovator of the Year. Columbus Tech Innovation Awards.
COE Harrison Award. College of Engineering, The Ohio State University.
Senior Member Status. American Institute of Chemical Engineers (AIChE).
Semi-finalist Columbus Tech Innovation Awards, Woman in Technology. TechColumbus.
Archer Award. Ohio STEM Ability Alliance.
Ohio State University Early Innovator Award. The Ohio State University.
Distinguished Undergraduate Research Mentor. Denman Research Forum.
COE Lumley Research Award. College of Engineering.
David C. McCarthy Engineering Teaching Award. College of Engineering.
Senior Member Status. IEEE Society.
Outstanding Undergraduate Achievement Mentor. The Ohio State University.
ACS Progress/Dreyfus Lectureship Award. American Chemical Society.
OSU Office of Technology Enhanced Learning and Research (TELR) Professional Development Grant (OSU). The Ohio State University.
NSF Graduate Research Fellowship. National Science Foundation.
Graduate Student Award. Biomedical Engineering Society.
MRS Gold Graduate Student Award. Materials Research Society.
IGERT Graduate Research Fellowship. University of Texas at Austin.
Rom Rhome Endowment for Professional Development in Material Science Travel Award. University of Texas at Austin.
IGERT Travel Award. University of Texas at Austin.
- S. Whitt, J.O. Winter. 2013. "Glowing Nanoparticles in the Brain." In Physics Principles and Problems, edited by Paul W. Zitzewitz, David G. Haase, Kathleen A. Harper, 770 - Columbus: McGraw Hill.
- S. Suri, G. Ruan, J. Winter, C. Schmidt. 2012. "Microparticles and Nanoparticles." In Biomaterials Science, edited by Buddy Ratner, Allan Hoffman, Frederick Schoen, Jack Lemons, 360 - 388. London: Elsevier.
- J.O. Winter. 2006. "Nanostructures for Celluar Engineering." In Tissue, Cell and Organ Engineering, edited by C. Kumar, 388 - 460. Weinheim: Wiley VHC.
- J.O. Winter, C.E. Schmidt. 2002. "Biomimetic Strategies and Applications in the Nervous System." In Biomimetic Materials and Design, edited by A.K. Dillow, A.M. Lowman, 375 - 415. New York: Marcel Dekker.
- A.D. Duong, G. Ruan, K. Mahajan, J.O. Winter, B.E. Wyslouzil, 2014, "Scalable, semi-continuous production of micelles encapsulating nanoparticles via electrospray." Langmuir 30, no. 14, 3939 - 3948.
- J. Xu, Q. Fan, K.D. Mahajan, G. Ruan, A. Herrington, K.F. Tehrani, P. Kner, J.O. Winter, 2014, "Micelle-templated composite quantum dots for super-resolution imaging." Nanotechnology 25, no. 19, 195601 -
- S.S. Rao, J.J. Lannutti, M.S. Viapiano, A. Sarkar, J.O. Winter, 2014, "Toward 3D Biomimetic Models to Understand the Behavior of Glioblastoma Multiforme Cells.." Tissue Engineering Part B Reviews. 20, no. 4, 314 - 327.
- C.J. Dorcena, K.M Olesik, O.G Wetta, J.O. Winter, 2013, "Characterization and Toxicity of Carbon Dot-Poly(lactic-co-glycolic acid) Nanocomposites for Biomedical Imaging." Nano LIFE 3, no. 1, 1340002 -
- S.S. Rao, T.M. Nelson, R. Xue, J.K. DeJesus, M.S. Viapiano, J.J. Lannutti, A. Sarkar, J.O. Winter, 2013, "Mimicking white matter tract topography using core-shell electrospun nanofibers to examine migration of malignant brain tumors." Biomaterials 34, no. 11, 5181 - 90.
- Rao,Shreyas,S; Dejesus,Jessica; Short,Aaron,R; Otero,Jose,J; Sarkar,Atom; Winter,Jessica,O, 2013, "Invited: Glioblastoma Behaviors in Three-Dimensional Collagen-Hyaluronan Composite Hydrogels." ACS APPLIED MATERIALS & INTERFACES 5, no. 19, 9276 - 9284.
- N. Han, P. Bradley, J. Johnson, K.S. Parikh, A. Hissong, J.J. Lannutti, J.O. Winter, 2013, "Effects of Hydrophobicity and Mat Thickness on Release from Hydrogel-Electrospun Fiber Mat Composites." Journal of Biomaterials Science, Polymer Edition 24, no. 17, 2018 - 30.
- K.D. Mahajan, Q. Fan, J. Dorcéna, G. Ruan, J.O. Winter, 2013, "Magnetic Quantum Dots in Biotechnology- Synthesis and Applications." Biotechnology Journal 8, 1424 - 1434.
- K.S. Parikh, S.S. Rao, H. Ansari, L.B. Zimmerman, L.J. Lee, S.A. Akbar, J.O. Winter, 2012, "Ceramic Nanopatterned Surfaces to Explore the Effects of Nanotopography on Cell Attachment." Materials Science and Engineering C 32, 2469–2475 -
- Han,Ning; Johnson,Jed; Lannutti,John,J; Winter,Jessica,O, 2012, "Hydrogel-electrospun fiber composite materials for hydrophilic protein release.." Journal of controlled release : official journal of the Controlled Release Society 158, no. 1, 165 - 170.
- K.D. Mahajan, G. Vieira, G. Ruan, B.L. Miller, M. Lustberg, J.J. Chalmers, R. Sooryakumar, J.O. Winter, 2012, "MagDot-Nanoconveyer Assay for Detection and Isolation of Molecular Biomarkers." Chemical Engineering Progress December 2012, 41 - 51.
- G. Ruan, J.O. Winter, 2012, "Chemical Engineering at the Intersection of Nanotechnology and Biology." Chemical Engineering Progress December 2012, 36 - 40.
- Xu,Jie; Mahajan,Kalpesh; Xue,Wei; Winter,Jessica,O; Zborowski,Maciej; Chalmers,Jeffrey,J, 2012, "Simultaneous, single particle, magnetization and size measurements of micron sized, magnetic particles." Journal of Magnetism and Magnetic Materials 324, no. 24, 4189 - 4199.
- Rao,Shreyas,S; Bentil,Sarah; Dejesus,Jessica; Larison,John; Hissong,Alex; Dupaix,Rebecca; Sarkar,Atom; Winter,Jessica,O, 2012, "Inherent Interfacial Mechanical Gradients in 3D Hydrogels Influence Tumor Cell Behaviors." PLOS ONE 7, no. 4, e35852 -
- N. Han, J. Johnson, P. Bradley, K.S. Parikh, J.J. Lannutti, J.O. Winter, 2012, "Cell Attachment to Hydrogel-Electrospun Fiber Mat Composite Materials." Journal of Functional Biomaterials 3, no. 3, 497 - 513.
- G. Ruan, J.O. Winter, 2011, "Alternating-color Quantum Dot Nanocomposites for Particle Tracking." Nano Letters 11, no. 3, 941 - 945.
- G. Ruan, D. Thakur, S. Deng, S. Hawkins, J.O. Winter, 2011, "Fluorescent-magnetic nanoparticles for imaging and cell manipulation." Journal of Nanoengineering and Nanosystems 223, no. N3/4, 81 - 86.
- S.S. Rao, N. Han, J.O. Winter, 2011, "Polylysine-Modified PEG-Based Hydrogels to Enhance the Neuro-Electrode Interface." JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 22, 611 - 625.
- Han,Ning; Rao,Shreyas,S; Johnson,Jed; Parikh,Kunal,S; Bradley,Patrick,A; Lannutti,John,J; Winter,Jessica,O, 2011, "Hydrogel-electrospun fiber mat composite coatings for neural prostheses.." Frontiers in neuroengineering 4, no. 2, 1 - 8.
- S. Deng, G. Ruan, N. Han, J.O. Winter, 2010, "Interactions in Fluorescent-Magnetic Heterodimer Nanocomposites." Nanotechnology 21, no. 14, 145605 -
- G. Ruan, G. Vieira, D. Thakur, T. Henighan, A. Chen, R. Sooryakumar, J.O. Winter, 2010, "Simultaneous Magnetic Manipulation and Fluorescent Tracking of Single Sub-100 nm Nanoparticles.." Nano Letters 10, no. 6, 2220 - 2224.
- N.A. Kotov, J.O. Winter, I.P. Clements, E. Jan, B.P. Timko, S. Campidelli, S. Pathak, A. Mazzatenta, C.M. Lieber, M. Prato, R.V. Bellamkonda, G.A. Silva, N.W. Shi Kam, F. Patolsky, L. Ballerini, 2009, Nanomaterials for Neural Interfaces. Advanced Materials 21, no. 40, 3970 - 4004.
- S.S. Rao, J.O. Winter, 2009, "Adhesion molecule-modified biomaterials for neural tissue engineering.." Frontiers In Neuroengineering 2, no. 6, 1 - 14.
- D. Thakur, S. Deng, T. Baldet, J.O. Winter, 2009, "pH Sensitive CdS-Iron Oxide Fluorescent-Magnetic Nanocomposites." Nanotechnology 20, no. 48, 485601 -
- J.O. Winter, M. Gokhale, R.J. Jensen, S.F. Cogan, J.F. Rizzo, 3rd, 2008, "Tissue Engineering Applied to the Retinal Prosthesis: Neurotrophin-Eluting Polymeric Hydrogel Coatings." Materials Science and Engineering C 28, no. 3, 448 - 453.
- Winter,Jessica,O; Cogan,Stuart,F; Rizzo,Joseph,F, 2007, "Retinal prostheses: current challenges and future outlook." JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 18, no. 8, 1031 - 1055.
- Winter,Jessica,O; Cogan,Stuart,F; Rizzo,Joseph,F, 2007, "Neurotrophin-Eluting Hydrogel Coatings for Neural Stimulating Electrodes." Journal of Biomedical Materials Research. Part B, Applied Biomaterials 81, no. 2, 551 - 563.
- Gomez,N; Winter,J,O; Shieh,F; Saunders,A,E; Korgel,B,A; Schmidt,C,E, 2005, "Challenges in Quantum Dot-Neuron Active Interfacing.." Talanta 67, no. 3, 462 - 471.
- Winter,J,O; Gomez,N; Gatzert,S; Schmidt,C,E; Korgel,B,A, 2005, "Variation of cadmium sulfide nanoparticle size and photoluminescence intensity with altered aqueous synthesis conditions." COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 254, no. 1-3, 147 - 157.
- J.O. Winter, T.Y. Liu, B.A. Korgel, C.E. Schmidt, 2001, "Recognition Molecule Directed Interfacing Between Semiconductor Quantum Dots and Nerve Cells." Advanced Materials 13, no. 22, 1673 - 1677.
- "Inherent Mechanical Gradients in 3D Matrigel Cultures Influence Tumor Cell Behaviors." 2011, Presented at AIChE Annual Meeting, Minneapolis,
- "Becoming a Woman Inventor and Entrepreneur." 2012, Presented at Professional Women's Resource Conference, Dayton,
- "Magnetic Quantum Dots and Magnetic Microarrays for Cell and Molecular Detection." 2012, Presented at 6th Annual International Conference on Bioengineering and Nanotechnology, Berkeley,
- "Tuning mechanics and surface chemistry independently in biomaterial scaffolds to modulate cell behavior." 2013, Presented at ACS National Meeting, New Orleans,
- "Magnetic quantum dot enabled technologies for nanoscale manipulation." 2013, Presented at ACS National Meeting, New Orleans,
- "Using Nanoparticles to Diagnose Disease." 2013, Presented at Coalition for National Science Funding, Washington, D.C.,
- "Neural Biomimetic Materials for Examining Cell Migration in Disease Progression." 2013, Presented at AIChE Annual Meeting, San Francisco,
- "Magnetic Quantum Dots for Quantitative Cell and Molecular Separations." 2014, Presented at Colloidal Semiconductor Nanoparticles Gordon Research Conference, Providence, US|USA
- "Nanotechnology for Cancer Detection." 2011, Presented at Seminar at Texas A&M University, College Station,
- "Nanoengineered Platform for Molecular Capture, Detection, and Manipulation." 2013, Presented at 4th International Conference on Bioengineering, Ft. Lauderdale,
- "Integrating Biological and Engineering Transport at the Nanoscale." 2013, Presented at Seminar at Northwestern University, Evanston,
- "Synthesis and Optimization of Polymer Micelles Formed Via Electroscopy-Enabled Interfacial Instability." 2013, Presented at AIChE Annual Meeting, San Francisco,
- "Toward Nanomachines: Bio-Inspired Assembly, Transport and Manipulation at the Nanoscale." 2014, Presented at Seminar at Northwestern University, Evanston,
- "Carbon-Iron Oxide Fluorescent-Magnetic Nanocomposites for In Vivo Imaging." 2011, Presented at AIChE Annual Meeting, Minneapolis,
- "Facile and Robust Fabrication of Sub-100 nm Poly(lactic-co-glycolic) acid Nanoparticle-based Drug Delivery Vehicles Via Self-Assembly." 2011, Presented at AIChE Annual Meeting, Minneapolis,
- "Multifunctional Nanocomposites for Single Cell and Molecule Manipulation." 2011, Presented at AIChE National Meeting, Minneapolis,
- "Magnetic Quantum Dots with Magnetic Microarrays for Molecular Detection and Separation." 2011, Presented at AIChE Annual Meeting, Minneapolis,
- "Fluorescent-Magnetic Nanomanipulators for Sensing and Separations." 2012, Presented at Sandia National Laboratories Center for Integrated Nanotechnologies User Conference, Albuquerque,
- "Nanoparticle-Based PCR-Less Detection and Isolation of Biomarkers." 2012, Presented at AIChE Annual Meeting, Pittsburgh,
- "Toxicity of Non-Cd-Based Fluorescent Nanoparticles for Biomedical Imaging." 2012, Presented at AIChE Annual Meeting, Pittsburgh,
- "Separating Magnetically Labeled and Unlabeled Biological Cells within Microfluidic Channels Using Magnetic Nanodisks." 2012, Presented at AIChE Annual Meeting, Pittsburgh,
- "Quantum Dots and Magnetic Quantum Dots for Biomedical Imaging and Separations." 2012, Presented at Seminar at Case Western Reserve University, Cleveland,
- "Towards an Engineered Nanofactory." 2013, Presented at Seminar at Sandia National Laboratories, Los Alamos,
- "Magnetic Quantum Dots for Imaging, Diagnostics, and Biomechanical Manipulation." 2014, Presented at Seminar at University of Texas, Austin, Austin,
- "Nanotechnology for Neural Engineering." 2012, Presented at Department of Biomedical Engineering, Texas A&M University, College Station,
- "Tunable, Aligned Electrospun Nanofiber White Matter Mimetics for Investigating Tumor Cell Migration." 2012, Presented at AIChE Annual Meeting, Pittsburgh,
- "Continuous Nanomanufacturing from Bench to Commercialization." 2013, Presented at Nano and Micro Manufacturing Workshop, Dearborn,
- "Engineering a Bio-Inspired Nanofactory for Assembly, Capture and Transport." 2013, Presented at Seminar at Department of Chemical Engineering, Auburn University, Auburn,
- "Towards a Biologically Inspired Nano-factory for Molecular Assembly, Capture, Transport, and Characterization." 2013, Presented at AIChE Annual Meeting, San Francisco,
- "Synthesis and Manipulation of Multifunctional, Fluorescent-Magnetic Nanoparticles for Single Molecule Tracking." 2010, Presented at SPIE Photonics West,
- "Fluorescent-Magnetic Nanoparticles for Imaging and Cell Manipulation." 2010, Presented at Nanotechnology and Nanoengineering, Edinburgh, GB|GBR
- "High Throughput Scalable Nanomanufacturing of Nanocomposites via Micellar Electrospray." 2014, Presented at 11th Korea-US Forum On Nanotechnology, Seoul, KR|KOR
- "Nanomaterials in Bioengineering: Tissue Engineering, Drug Delivery, and Imaging." 2014, Presented at Heaven and Earth Distinguished Lecture at Nanjing University, Nanjing, CN|CHN
Papers in Proceedings
- Q. Fan, G. Nabar, C. Miller, C. Castro, J. Winter "Photo-switchable quantum dots based on reversible FRET." JOURNAL: "Proceedings of SPIE: Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XI." in Proceedings of SPIE: Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XI. (7 2014). 89540D -
- M.L. Howdyshell, M. Prikockis, S. Lauback, G.B. Vieira, K. Mahajan,J. Winter, R. Sooryakumar "Deterministic and stochastic trajectories of magnetic particles: Mapping energy landscapes for technology and biology." in IEEE Transactions on Magnetics.
- J.O. Winter, G. Ruan. "Centrifugation-assisted Magnetic Separation of Magnetic Nanoparticles, and Methods of Use."
- J.O. Winter, D. Thakur. "Biocompatible fluorescent carbon nanoparticles from carbon black, and Formulations Thereof, and Methods of Use."
- J.O. Winter, G. Ruan. "Nanocontainers of Block Copolymer Micelles to Co-encapsulate Multiple Types of Nanospecies, and Formulations Thereof, and Methods of Use." Patent number: 61/483,091
- B. Wyslouzil, J.O. Winter, T. Doug, G. Ruan. "Semi-continuous, Large Scale Production Process of Sub-100 nm Hybrid Nanoparticles by Electrospray Coupled with Self-assembly."
- J.O. Winter and G. Ruan. "Non-Blinking and Color-Changing Nanoparticles for Single Particle Tracking."
- J.O. Winter, K. Mahajan, G. Ruan. "Method to Use Self-assembly to Fabricate Polymeric Nanoparticles with Sub-100 nm Size, Narrow Size Distribution, Controllable Shape, and Versatile Molecular Release Kinetics, and the Resultant Nanodevice." Patent number: 61/433,794
- J.O. Winter, R. Sooryakumar, K. Mahajan, G. Vieira, G. Ruan, A. Chen. "One pot separation and analysis of biomarkers by nano-conveyor belts."
- J.O. Winter, K. Mahajan, G. Ruan, A. Duong, B. Wyslouzil. "Methods for Producing Nanoparticles and Using Same."
- J.O. Winter, H. Chander. "Nanopatterned Contact Lenses to Promote Corneal Wound Healing."
- J.O. Winter, K. Mahajan, Q. Fan. "An engineered nanofactory for reversible nanoassembly and transport."
- J.O. Winter, G. Ruan, Q. Fan. "Quantum Dot Light Switches: Photo-switchable quantum dots based on light-modulated fluorescence resonant energy transfer."