Swindle-Reilly group's research featured on cover of Journal of Controlled Release

Posted: April 27, 2020
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A team of researchers led by Katelyn Swindle-Reilly, an assistant professor in the departments of Biomedical Engineering (BME), Chemical and Bimolecular Engineering (CBE), and Ophthalmology, had their research featured on the cover of the Journal of Controlled Release.

The research article, “Injectable biodegradable bi-layered capsule for sustained delivery of bevacizumab in treating wet age-related macular degeneration”, introduces a new mechanism for the long-term release of bevacizumab, a drug used to treat wet age-related macular degeneration.

Previously, maintaining high concentrations of bevacizumab (anti-VEGF) in the body was difficult due to insufficient drug loading capacity and drug-device interactions. To overcome this, the team developed a polymeric based bi-layered capsule that could address these challenges by extending the release over one year, thereby providing an effective platform to enable treatment of chronic vascular diseases. By providing optimal physical trapping and electrostatic interaction, the capsule structure ensures the appropriate release of bevacizumab over time.

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The research team consisted of Katelyn Swindle-Reilly, chemical engineering doctoral student Pengfei Jiang, Professor Andre Palmer (chemical engineering), Matthew Ohr, physician and associate professor in ophthalmology, John Lannutti, professor in materials science, Francisco Chaparro, PhD graduate in materials science, and Clayton Cuddington, doctoral student in chemical engineering. 

Congratulations Dr. Swindle-Reilly and Team!

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