Eduardo Reátegui Group for Bioengineering Research
About
Dr. Reátegui’s research integrates microtechnologies, biomaterials, and molecular imaging strategies for high-throughput sorting and molecular profiling of circulating biomarkers; as well as the development of infection/inflammation on-a-chip devices for the biophysical and molecular characterization of immune cells at the single-cell level and their interactions with pathogens.
Dr. Eduardo Reátegui is an assistant professor in the Department of Chemical and Biomolecular Engineering at The Ohio State University. He is also a member of the Molecular Biology and Cancer Genetics Program at the James Comprehensive Cancer Center.
He obtained his Ph.D. at the University of Minnesota in 2012 and his BS degree in Engineering from the Universidad Nacional de Ingenieria in Lima, Perú. His doctoral thesis focused on the development of inorganic biomaterials and polymeric nanointerfaces with tunable properties for reversible encapsulation of proteins and cells.
After graduation, he was a postdoctoral research fellow at Harvard Medical School and the Massachusetts General Hospital Cancer Center in Boston.
Professor Reátegui bridges engineering disciplines with biology to exploit complex cellular interactions and mechanisms towards the goal of solving unmet needs in life sciences and medicine.
The Reátegui research group focuses on the development of translational microtechnologies combining microfluidics, biomaterials, and molecular imaging techniques to help better diagnose, study, and treat cancer and infectious diseases.
Projects include the design and integration of biodegradable nanofilms for microfluidic devices that enabled the selective recovery of circulating tumor biomarkers, including circulating tumor cells (CTCs) and tumor extracellular vesicles (tEVs) for downstream molecular characterization.
Currently, Professor Reátegui is working on expanding the applications of circulating biomarkers not only as a diagnostic tool, but also exploring their role in cancer metastisis and cell-to-cell communication with the immune system.
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Faculty Member |
Molecular Biology and Cancer Genetics Program, Comprehensive Cancer Center |
08/2017-present |
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Faculty Member |
Host Defense and Microbial Biology Program, Institute of Infectious Diseases
Prevention, Detection and Therapies Program, Institute of Infectious Diseases
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08/2017-present
08/2017-present |
KEY DISTINCTIONS
- 5 patents
- Invented the neutrophil swarming on a chip platform that enabled high throughput characterization of soluble factors, and inflammation EVs (iEVs) produced from neutrophils during the onset of inflammation.
- His doctoral work provided the foundation for launching Minnepura Technologies, a start-up company at the University of Minnesota.
- Best Dissertation Award, Physical Sciences and Engineering, University of Minnesota, 2012
- Doctoral Disertation Fellowship, University of Minnesota, 2010
- First Class Honors, Department of Mechanical Engineering, Universidad Nacional de Ingenieria, 2004
NATIONAL AND INTERNATIONAL
- Invited Speaker Award, Gordon Research Conference on Rare Cells in Circulation, 2016
- Young Investigator Travel Award, International Society of Extracellular Vesicles Conference, 2015
- Best Poster Award, Circulating Biomarkers Conference, 2014
- Travel Award and Best Poster Award (2009), The Physics, Chemistry, and Biology of Water Conference, 2009, 2010
- Travel Award, USA-Mexico Workshop in Biological Chemistry, Mexico City, 2009
- Best Poster Award Sigma Xi Research Exhibition, University of Massachusetts, 2005
- Best Research Undergraduate Project, Ministry of Energy and Mines, Perú, 2003
- Fourth place, International IV Program of Energy and Environment, Ministry of Energy and Mines, Peru, 2004
REGIONAL
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Lumley Research Award, The Ohio State University College of Engineering, 2021
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First Class Honors
Mechanical Engineering, Universidad Nacional de Ingenieria; Lima, Perú, 2002
Research
The Reátegui Research Group at Ohio State integrates microtechnologies, biomaterials, and molecular imaging strategies for high-throughput sorting and molecular profiling of circulating cancer biomarkers; as well as the development of infection/inflammation on-a-chip devices for physical and chemical characterization of immune cell interactions with pathogens and cancer cells.
NOVEL APPROACH FOR ISOLATION AND ENRICHMENT OF EXTRACELLULAR VESICLES CHARACTERIZATION OF MOLECULAR CARGO OF SINGLE EXTRACELLULAR VESICLES
Innovation: Eduardo Reátegui’s approach to isolate and enrich extracellular vesicles (EVs) uses a combination of ultrafiltration and immunomagnetic separation to achieve high levels of specificity and sensitivity when compared to other commercially available methods for EV purification.
Impact: Reátegui’s EV purification technique works with either small or large amounts of different types of biofluids (e.g., urine) and removes up to 99.9 % of contaminants present in a sample.
