William G. Lowrie Department of Chemical and Biomolecular Engineering

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Barbara Wyslouzil

ProfessorChemistry and Biochemistry
ProfessorChemical and Biomolecular Engineering

231B Koffolt Laboratories
140 W Nineteenth Ave
Columbus, OH 43210

614-688-3583

About Me


Education

  • B. Sc. (Honors) Mathematics and Engineering, Queens University, 1980
  • M.Sc., Chemical Engineering, University of Alberta, 1985
  • Ph.D., Chemical Engineering (minor: Applied Physics), California Institute of Technology, 1992

Key Honors and Distinctions

  • OSU College of Engineering Lumley Research Award, 2009
  • Kenneth T. Whitby Award for Outstanding Contributions to Aerosol Science and Technology by a Beginning Scientist, American Association for Aerosol Research, 2002
  • WPI Trustees Award for Outstanding Research and Creative Scholarship, 2001
  • Japan Society for the Promotion of Science Fellowship, 1996
  • National Science Foundation Career Development Award, 1995

Research Interests

  • Aerosol Physics, Nucleation, Biomedical Aerosol Applications

Our research projects all contain some aspect or application of aerosol science. Currently we are conducting experiments to probe the microstructure and composition of nanodroplets, and to measure nucleation rates in supersonic nozzles. Models of multicomponent condensation in supersonic flows complement the experimental work. Our group is also active in developing biological and biomedical applications of aerosol science.

Nanodroplet Structure
Even in the liquid state, the composition of multicomponent nanometer-sized droplets is highly non-uniform despite their small size and the relatively short diffusion times.  Surface enrichment in aerosols affects the heterogeneous chemistry of aerosol particles as well as nucleation, growth and evaporation kinetics. Our research group uses small angle neutron scattering (SANS) and tunable laser diode absorption spectroscopy (TDLAS) to probe the structure and composition of nanodroplets in order to develop a better understanding of how molecules segregate within aerosol droplets.

Nucleation and Condensation
In most industrial applications and in the atmosphere, more than one condensible species is present, and the rates of new particle formation and growth may be severely under predicted if interactions between the species are ignored. In our group we use a continuous flow supersonic nozzle apparatus to explore nucleation, condensation, and aerosol evolution at supersaturations and expansion rates that are comparable to those found in turbomachinery, jet exhausts, and steam turbines. By conducting small angle neutron scattering and pressure trace experiments, nucleation rates can be measured that are 6 – 8 orders of magnitude higher than in any other type of equipment.

Biomedical Applications
Our research group also collaborates actively with colleagues on bio-related aerosol problems. Our current research focuses on developing aerosol based delivery systems for tissue therapy.

Honors

2009

  • Lumley Research Award, John H. and Mildred C. Lumley

2002

  • Kenneth T. Whitby Award for Outstanding Contributions to Aerosol Science and Technology by a Beginning Scientist, American Association for Aerosol Research

2001

  • WPI Trustees Award for Outstanding Research and Creative Scholarship, Worcester Polytechnic Institute

1996

  • Fellowship, Japan Society for the Promotion of Science

1995

  • NSF Career Award, National Science Foundation

Journal Articles

2012

  • Manka,Alexandra; Pathak,Harshad; Tanimura,Shinobu; Woelk,Judith; Strey,Reinhard; Wyslouzil,Barbara,E, "Freezing water in no-man's land." PHYSICAL CHEMISTRY CHEMICAL PHYSICS 14 13 4505-4516

2011

  • Wu,Yun; Ma,NingNing; Wyslouzil,Barbara,E; Chalmers,Jeffrey,J; McCormick,Ellen; Casnocha,Susan,A, "Enhanced Productivity of NS0 Cells in Fed-Batch Culture with Cholesterol Nanoparticle Supplementation." BIOTECHNOLOGY PROGRESS 27 3 796-802
  • Laksmono,Hartawan; Tanimura,Shinobu; Wyslouzil,Barbara,E, "Methanol nucleation in a supersonic nozzle." JOURNAL OF CHEMICAL PHYSICS 135 7
  • Wyslouzil,Barbara,E, "Monomer, clusters, liquid: How does methanol condense?." ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 242
  • Williams,Natalie,E; Wyslouzil,Barbara; Duong,Tony; Henderson,Lauren; LaiHing,Kenneth, "Optimization of particle size in lipoplex nanoparticle fabrication." ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 241
  • Bhabhe,Ashutosh; Wyslouzil,Barbara, "Nitrogen nucleation in a cryogenic supersonic nozzle." JOURNAL OF CHEMICAL PHYSICS 135 24
  • Laksmono,Hartawan; Tanimura,Shinobu; Allen,Heather,C; Wilemski,Gerald; Zahniser,Mark,S; Shorter,Joanne,H; Nelson,David,D; McManus,J,Barry; Wyslouzil,Barbara,E, "Monomer, clusters, liquid: an integrated spectroscopic study of methanol condensation." PHYSICAL CHEMISTRY CHEMICAL PHYSICS 13 13 5855-5871

2010

  • Tanimura,Shinobu; Dieregsweiler,Uta,M; Wyslouzil,Barbara,E, "Binary nucleation rates for ethanol/water mixtures in supersonic Laval nozzles." JOURNAL OF CHEMICAL PHYSICS 133 17
  • Liang,D; Allen,H,C; Frankel,G,S; Chen,Z,Y; Kelly,R,G; Wu,Y; Wyslouzil,B,E, "Effects of Sodium Chloride Particles, Ozone, UV, and Relative Humidity on Atmospheric Corrosion of Silver." JOURNAL OF THE ELECTROCHEMICAL SOCIETY 157 4 C146-C156
  • Sinha,Somnath; Bhabhe,Ashutosh; Laksmono,Hartawan; Wölk,Judith; Strey,Reinhard; Wyslouzil,Barbara, "Argon nucleation in a cryogenic supersonic nozzle.." journal of chemical physics 132 6 064304-?
  • Tanimura,Shinobu; Wyslouzil,Barbara,E; Wilemski,Gerald, "CH3CH2OD/D2O binary condensation in a supersonic Laval nozzle: Presence of small clusters inferred from a macroscopic energy balance." JOURNAL OF CHEMICAL PHYSICS 132 14
  • Kim,Yoojeong; Gidwani,Ashok; Wyslouzil,Barbara,E; Sohn,Chang,W, "Source term models for fine particle resuspension from indoor surfaces." BUILDING AND ENVIRONMENT 45 8 1854-1865
  • Tanimura,Shinobu; Dieregsweiler,Uta,M; Wyslouzil,Barbara,E, "Binary nucleation rates for ethanol/water mixtures in supersonic Laval nozzles (vol 133, 174305, 2010)." JOURNAL OF CHEMICAL PHYSICS 133 19
  • Ghosh,David; Bergmann,Dirk; Schwering,Regina; Woelk,Judith; Strey,Reinhard; Tanimura,Shinobu; Wyslouzil,Barbara,E, "Homogeneous nucleation of a homologous series of n-alkanes (CiH2i+2, i=7-10) in a supersonic nozzle." JOURNAL OF CHEMICAL PHYSICS 132 2
  • Wu,Yun; Fei,Zhengzheng; Lee,L,James; Wyslouzil,Barbara,E, "Coaxial Electrohydrodynamic Spraying of Plasmid DNA/Polyethylenimine (PEI) Polyplexes for Enhanced Nonviral Gene Delivery." BIOTECHNOLOGY AND BIOENGINEERING 105 4 834-841
  • Wyslouzil,Barbara,E; Manka,Alexandra; Woelk,Judith; Strey,Reinhard, "Freezing of supercooled water nanodroplets." ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 240
  • Sinha,Somnath; Bhabhe,Ashutosh; Laksmono,Hartawan; Woelk,Judith; Strey,Reinhard; Wyslouzil,Barbara, "Argon nucleation in a cryogenic supersonic nozzle." JOURNAL OF CHEMICAL PHYSICS 132 6

2009

  • Wu,Yun; Chalmers,Jeffrey,J; Wyslouzil,Barbara,E, "The Use of Electrohydrodynamic Spraying to Disperse Hydrophobic Compounds in Aqueous Media." AEROSOL SCIENCE AND TECHNOLOGY 43 9 902-910
  • Sinha,Somnath; Wyslouzil,Barbara,E; Wilemski,Gerald, "Modeling of H2O/D2O Condensation in Supersonic Nozzles." AEROSOL SCIENCE AND TECHNOLOGY 43 1 9-24

2008

  • Sinha,Somnath; Laksmono,Hartawan; Wyslouzil,Barbara,E, "A cryogenic supersonic nozzle apparatus to study homogeneous nucleation of Ar and other simple molecules." REVIEW OF SCIENTIFIC INSTRUMENTS 79 11
  • Van Loon,Lisa,L; Allen,Heather,C; Wyslouzil,Barbara,E, "Effective Diffusion Coefficients for Methanol in Sulfuric Acid Solutions Measured by Raman Spectroscopy." JOURNAL OF PHYSICAL CHEMISTRY A 112 43 10758-10763
  • Wyslouzil,Barbara,E; Wilemski,Gerald; Strey,Reinhard; Seifert,Soenke; Winans,Randall,E, "Small angle X-ray scattering measurements probe water nanodroplet evolution under highly non-equilibrium conditions (vol 9, pg 5353, 2007)." PHYSICAL CHEMISTRY CHEMICAL PHYSICS 10 48 7327-7328
  • Ghosh,David; Manka,Alexandra; Strey,Reinhard; Seifert,Soenke; Winans,Randall,E; Wyslouzil,Barbara,E, "Using small angle x-ray scattering to measure the homogeneous nucleation rates of n-propanol, n-butanol, and n-pentanol in supersonic nozzle expansions." JOURNAL OF CHEMICAL PHYSICS 129 12

2007

  • Wyslouzil,Barbara,E; Wilemski,Gerald; Strey,Reinhard; Seifert,Soenke; Winans,Randall,E, "Small angle X-ray scattering measurements probe water nanodroplet evolution under highly non-equilibrium conditions." PHYSICAL CHEMISTRY CHEMICAL PHYSICS 9 39 5353-5358
  • Tanimura,Shinobu; Wyslouzil,Barbara,E; Zahniser,Mark,S; Shorter,Joanne,H; Nelson,David,D; McManus,Barry, "Tunable diode laser absorption spectroscopy study of CH3CH2OD/D2O binary condensation in a supersonic Laval nozzle." JOURNAL OF CHEMICAL PHYSICS 127 3
  • Wyslouzil,Barbara,E; Wilemski,Gerald; Strey,Reinhard; Woelk,Judith; Kim,Yoo,Jeong, "Isothermal nucleation rates in supersonic nozzles and the properties of small water clusters." ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 233 585-585
  • Towler,Melissa,J; Wyslouzil,Barbara,E; Weathers,Pamela,J, "Using an aerosol deposition model to increase hairy root growth in a mist reactor." BIOTECHNOLOGY AND BIOENGINEERING 96 5 881-891

2006

  • Wang,Hai; Zhao,Bin; Wyslouzil,Barbara,E; Kim,Yoo,Jeong, "Spatially-resolved measurement of soot dynamics by small angle neutron scattering in a heavily sooting flame." ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 231
  • Wyslouzil,B,E; Wilemski,G; Strey,R; Heath,C,H; Dieregsweiler,U, "Experimental evidence for internal structure in aqueous - organic nanodroplets." PHYSICAL CHEMISTRY CHEMICAL PHYSICS 8 1 54-57
  • Wyslouzil,Barbara,E; Wilemski,Gerald; Strey,Reinhard, "Structure at the interface of nanodroplets." ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 231

2005

  • Roberts,A; Wyslouzil,B,E; Bonassar,L, "Aerosol delivery of mammalian cells for tissue engineering." BIOTECHNOLOGY AND BIOENGINEERING 91 7 801-807
  • Tanimura,Shinobu; Zvinevich,Yury; Wyslouzil,Barbara,E; Zahniser,Mark; Shorter,Joanne; Nelson,David; McManus,Barry, "Temperature and gas-phase composition measurements in supersonic flows using tunable diode laser absorption spectroscopy: the effect of condensation on the boundary-layer thickness.." journal of chemical physics 122 19 194304-?
  • Tanimura,S; Zvinevich,Y; Wyslouzil,B,E, "Temperature and gas-phase composition measurements in supersonic flows using tunable diode laser absorption spectroscopy: The effect of condensation on the boundary-layer thickness - art. no. 194303." JOURNAL OF CHEMICAL PHYSICS 122 19
  • Gharibeh,M; Kim,Y; Dieregsweiler,U; Wyslouzil,B,E; Ghosh,D; Strey,R, "Homogeneous nucleation of n-propanol, n-butanol, and n-pentanol in a supersonic nozzle." JOURNAL OF CHEMICAL PHYSICS 122 9

2004

  • Paci,P; Zvinevich,Y; Tanimura,S; Wyslouzil,B,E; Zahniser,M; Shorter,J; Nelson,D; McManus,B, "Spatially resolved gas phase composition measurements in supersonic flows using tunable diode laser absorption spectroscopy." JOURNAL OF CHEMICAL PHYSICS 121 20 9964-9970
  • Kim,Y,J; Wyslouzil,B,E; Wilemski,G; Wolk,J; Strey,R, "Isothermal nucleation rates in supersonic nozzles and the properties of small water clusters." JOURNAL OF PHYSICAL CHEMISTRY A 108 20 4365-4377

2003

  • Kim,Y,J; Weathers,P,J; Wyslouzil,B,E, "Growth dynamics of Artemisia annua hairy roots in three culture systems." BIOTECHNOLOGY AND BIOENGINEERING 83 4 428-443
  • Khan,A; Heath,C,H; Dieregsweiler,U,M; Wyslouzil,B,E; Strey,R, "Homogeneous nucleation rates for D2O in a supersonic Laval nozzle." JOURNAL OF CHEMICAL PHYSICS 119 6 3138-3147
  • Heath,C,H; Streletzky,K,A; Wyslouzil,B,E; Wolk,J; Strey,R, "Small angle neutron scattering from D2O-H2O nanodroplets and binary nucleation rates in a supersonic nozzle." JOURNAL OF CHEMICAL PHYSICS 118 12 5465-5473

2002

  • Heath,C,H; Streletzky,K; Wyslouzil,B,E; Wolk,J; Strey,R, "H2O-D2O condensation in a supersonic nozzle." JOURNAL OF CHEMICAL PHYSICS 117 13 6176-6185
  • Streletzky,K,A; Zvinevich,Y; Wyslouzil,B,E; Strey,R, "Controlling nucleation and growth of nanodroplets in supersonic nozzles." JOURNAL OF CHEMICAL PHYSICS 116 10 4058-4070
  • Kim,Y,J; Weathers,P,J; Wyslouzil,B,E, "Growth of Artemisia annua hairy roots in liquid- and gas-phase reactors." BIOTECHNOLOGY AND BIOENGINEERING 80 4 454-464
  • Kim,Y; Wyslouzil,B,E; Weathers,P,J, "Invited review: Secondary metabolism of hairy root cultures in bioreactors." IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT 38 1 1-10
  • Wolk,J; Strey,R; Heath,C,H; Wyslouzil,B,E, "Empirical function for homogeneous water nucleation rates." JOURNAL OF CHEMICAL PHYSICS 117 10 4954-4960

2001

  • Kim,Y; Wyslouzil,B,E; Weathers,P,J, "A comparative study of mist and bubble column reactors in the in vitro production of artemisinin." PLANT CELL REPORTS 20 5 451-455

2000

  • Wyslouzil,B,E; Wilemski,G; Strey,R, "Aerosol SANS: A new method to probe the structure of nanodroplets.." ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 220 U164-U165
  • Wyslouzil,B,E; Waterbury,R,G; Weathers,P,J, "The growth of single roots of Artemisia annua in nutrient mist reactors." BIOTECHNOLOGY AND BIOENGINEERING 70 2 143-150
  • Wyslouzil,B,E; Heath,C,H; Cheung,J,L; Wilemski,G, "Binary condensation in a supersonic nozzle." JOURNAL OF CHEMICAL PHYSICS 113 17 7317-7329

1999

  • Wyslouzil,B,E; Wilemski,G, "Binary nucleation kinetics. V. Phi lines and evaporation rate surfaces." JOURNAL OF CHEMICAL PHYSICS 110 2 1202-1211
  • Wyslouzil,B,E; Wilemski,G; Cheung,J,L; Strey,R; Barker,J, "Doppler shift anisotropy in small angle neutron scattering." PHYSICAL REVIEW E 60 4 4330-4335

1997

  • Wyslouzil,B,E; Cheung,J,L; Wilemski,G; Strey,R, "Small angle neutron scattering from nanodroplet aerosols." PHYSICAL REVIEW LETTERS 79 3 431-434
  • Wyslouzil,B,E; Whipple,M; Chatterjee,C; Walcerz,D,B; Weathers,P,J; Hart,D,P, "Mist deposition onto hairy root cultures: Aerosol modeling and experiments." BIOTECHNOLOGY PROGRESS 13 2 185-194
  • Chatterjee,C; Correll,M,J; Weathers,P,J; Wyslouzil,B,E; Walcerz,D,B, "Simplified acoustic window mist bioreactor." BIOTECHNOLOGY TECHNIQUES 11 3 155-158

1996

  • Wyslouzil,B,E; Wilemski,G, "Binary nucleation kinetics .3. Transient behavior and time lags." JOURNAL OF CHEMICAL PHYSICS 105 3 1090-1100

1995

  • Wyslouzil,B,E; Wilemski,G, "BINARY NUCLEATION KINETICS .2. NUMERICAL-SOLUTION OF THE BIRTH-DEATH EQUATIONS." JOURNAL OF CHEMICAL PHYSICS 103 3 1137-1151
  • Wilemski,G; Wyslouzil,B,E, "BINARY NUCLEATION KINETICS .1. SELF-CONSISTENT SIZE DISTRIBUTION." JOURNAL OF CHEMICAL PHYSICS 103 3 1127-1136
  • Shinagawa,H; Miyamoto,K,I; Okuyama,K; Wyslouzil,B,E, "SIMULATION OF A TRANSIENT HETEROGENEOUS PHASE-TRANSITION." JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 28 4 456-461
  • Whipple,M; Wyslouzil,B; WEATHERS,P, "DEPOSITION OF NUTRIENT MIST PARTICLES ONTO HAIRY ROOT CULTURES." ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 209 64-BIOT

1994

  • Shinagawa,H; Hamada,T; Okuyama,K; Wyslouzil,B,E, "A THEORETICAL EVALUATION OF LIQUID CONDENSATE FORMATION BY HETEROGENEOUS NUCLEATION FROM A BENZENE AND CYCLOHEXANE VAPOR MIXTURE." JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 27 2 249-253
  • Wyslouzil,B,E; Wilemski,G; BEALS,M,G; Frish,M,B, "EFFECT OF CARRIER GAS-PRESSURE ON CONDENSATION IN A SUPERSONIC NOZZLE." PHYSICS OF FLUIDS 6 8 2845-2854
  • Shinagawa,H; Hamada,T; Okuyama,K; Wyslouzil,B,E, "A THEORETICAL EVALUATION OF LIQUID CONDENSATE FORMATION BY HETEROGENEOUS NUCLEATION FROM A BENZENE AND CYCLOHEXANE VAPOR MIXTURE (VOL 27, PG 250, 1994)." JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 27 5 U3-U3
  • Shinagawa,H; Miyamoto,K; Hamada,T; Okuyama,K; Wyslouzil,B,E, "DETERMINING THE PHASE-TRANSITION OF CONDENSATE FORMED BY HETEROGENEOUS NUCLEATION OF CONDENSABLE VAPORS ONTO A COLD SUBSTRATE." JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 27 3 284-290

1992

  • Wyslouzil,B,E; Seinfeld,J,H, "NONISOTHERMAL HOMOGENEOUS NUCLEATION." JOURNAL OF CHEMICAL PHYSICS 97 4 2661-2670

1991

  • Wyslouzil,B,E; Seinfeld,J,H; Flagan,R,C; Okuyama,K, "BINARY NUCLEATION IN ACID WATER-SYSTEMS .2. SULFURIC-ACID WATER AND A COMPARISON WITH METHANESULFONIC-ACID WATER." JOURNAL OF CHEMICAL PHYSICS 94 10 6842-6850
  • Wyslouzil,B,E; Seinfeld,J,H; Flagan,R,C; Okuyama,K, "BINARY NUCLEATION IN ACID WATER-SYSTEMS .1. METHANESULFONIC-ACID WATER." JOURNAL OF CHEMICAL PHYSICS 94 10 6827-6841

1987

  • Wyslouzil,B,E; KESSICK,M,A; Masliyah,J,H, "PIPELINE FLOW BEHAVIOR OF HEAVY CRUDE-OIL EMULSIONS." CANADIAN JOURNAL OF CHEMICAL ENGINEERING 65 3 353-360
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